Luangwa is well known for large populations of all the major African mammals (with the exception of rhino, which were poached to extinction in the 80s - but are being reintroduced into North Luangwa). It has a reputation for some of the best leopard sightings in Africa. This is partly because of the ideal nature of the habitat which includes thick riverine bush with plenty of cover, lots of game and some large shady trees to lie up in and also, unlike many parks in Africa, night game driving is allowed.

There are bush buck, puku, kudu, impala, zebra (although not many in the south) the indigenous Thornicroft giraffe and all the main predators, lion, leopard etc, including wild dog and the smaller predators such as genet, civet, mongoose etc. The bird life is excellent and very vocal with the oxbows and river attracting a vast number of water birds.

The game viewing is outstanding up near Mfuwe (the park entrance) where the animals are very used to vehicles all year round. Mfuwe area is also quite busy, so you have to be prepared for other vehicles which you really notice at night because of the spot lights used on night drives. The lodges around Mfuwe (such as {Mfuwe Lodge},{Kapani Lodge} and {Kuyenda}) are usually a base from which to go into the park and with the game being so habituated in the area, it is an idea to have a night or two at the beginning of the trip for some game drives and night drives and to then head off into the bush for the walking.

The north park and Nsefu sector which has camps such as {Tena Tena}, {Nsefu}, {Kaingo Camp}, {Mchenja Bushcamp} and {Tafika Camp}, is particularly beautiful with some really very impressive ebony groves. These tall and majestic trees give a dreamy dappled shade to almost lawn like grass underneath and are a haven for the game. The area is also generally more open with the huge Mtanda Plains and hot springs/salt pans which certainly at the beginning of the season makes for slightly easier game viewing.